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cell line sk-hep-1 cl-0212  (Procell Inc)

 
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    Procell Inc cell line sk-hep-1 cl-0212
    KDM5C is highly expressed in <t>LIHC</t> and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells
    Cell Line Sk Hep 1 Cl 0212, supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell line sk-hep-1 cl-0212/product/Procell Inc
    Average 90 stars, based on 1 article reviews
    cell line sk-hep-1 cl-0212 - by Bioz Stars, 2026-03
    90/100 stars

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    1) Product Images from "Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma"

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    Journal: The Kaohsiung Journal of Medical Sciences

    doi: 10.1002/kjm2.12501

    KDM5C is highly expressed in LIHC and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells
    Figure Legend Snippet: KDM5C is highly expressed in LIHC and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells

    Techniques Used: Expressing, Quantitative RT-PCR, Western Blot

    Downregulation of KDM5C weakens proliferation, migration, and invasion, and increases apoptosis of LIHC cells. (A) interference efficiency of sh‐KDM5C 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) proliferation of cells examined by the CCK‐8 assay; (C) colony formation ability of cells determined by the colony formation assay; (D) apoptosis rate in cells examined by TUNEL assay; (E) migration ability of cells examined by the wound‐healing assay; (F) invasion ability of cells determined by the Transwell assay. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group
    Figure Legend Snippet: Downregulation of KDM5C weakens proliferation, migration, and invasion, and increases apoptosis of LIHC cells. (A) interference efficiency of sh‐KDM5C 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) proliferation of cells examined by the CCK‐8 assay; (C) colony formation ability of cells determined by the colony formation assay; (D) apoptosis rate in cells examined by TUNEL assay; (E) migration ability of cells examined by the wound‐healing assay; (F) invasion ability of cells determined by the Transwell assay. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group

    Techniques Used: Migration, Quantitative RT-PCR, CCK-8 Assay, Colony Assay, TUNEL Assay, Wound Healing Assay, Transwell Assay

    ITIH1 level is negatively correlated with the KDM5C level in LIHC. (A) Genes showing a negative correlation with KDM5C in LIHC predicted in the Ualcan database (ranked in order of correlation; color depth of the blocks indicates the basic expression level of gene in LIHC); (B) expression profiling of ITIH1 in human cancers predicted in the SangerBox system; (C) correlation between ITIH1 and the survival of patients with LIHC predicted in the GEPIA database; (D) correlation between ITIH1 and KDM5C in patients with LIHC predicted in the Starbase system; (E and F) mRNA (E) and protein (F) levels of ITIH1 in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (E) and (F), differences were analyzed by one‐way ANOVA, * p < 0.05 versus the THLE‐3 cells
    Figure Legend Snippet: ITIH1 level is negatively correlated with the KDM5C level in LIHC. (A) Genes showing a negative correlation with KDM5C in LIHC predicted in the Ualcan database (ranked in order of correlation; color depth of the blocks indicates the basic expression level of gene in LIHC); (B) expression profiling of ITIH1 in human cancers predicted in the SangerBox system; (C) correlation between ITIH1 and the survival of patients with LIHC predicted in the GEPIA database; (D) correlation between ITIH1 and KDM5C in patients with LIHC predicted in the Starbase system; (E and F) mRNA (E) and protein (F) levels of ITIH1 in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (E) and (F), differences were analyzed by one‐way ANOVA, * p < 0.05 versus the THLE‐3 cells

    Techniques Used: Expressing, Quantitative RT-PCR, Western Blot

    KDM5C removes H3K4me1 to reduce ITIH1 expression in LIHC cells. (A) Methylation modification at the promoter region of ITIH1 predicted in the UCSC database; (B) mRNA level of ITIH1 in cells transfected with sh‐KDM5C examined by RT‐qPCR; (C and D) H3K4me1 (C) and KDM5C (D) modification levels at ITIH1 promoter region in LIHC cell lines (Hep3B, SNU‐387, HuH‐7 and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by ChIP‐qPCR; E, protein levels of ITIH1 and H3K4me1 in cells transfected sh‐KDM5C examined by western blot analysis. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA; in panels (B)–(E), differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group; # p < 0.01 versus THLE‐3 cells
    Figure Legend Snippet: KDM5C removes H3K4me1 to reduce ITIH1 expression in LIHC cells. (A) Methylation modification at the promoter region of ITIH1 predicted in the UCSC database; (B) mRNA level of ITIH1 in cells transfected with sh‐KDM5C examined by RT‐qPCR; (C and D) H3K4me1 (C) and KDM5C (D) modification levels at ITIH1 promoter region in LIHC cell lines (Hep3B, SNU‐387, HuH‐7 and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by ChIP‐qPCR; E, protein levels of ITIH1 and H3K4me1 in cells transfected sh‐KDM5C examined by western blot analysis. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA; in panels (B)–(E), differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group; # p < 0.01 versus THLE‐3 cells

    Techniques Used: Expressing, Methylation, Modification, Transfection, Quantitative RT-PCR, ChIP-qPCR, Western Blot

    KDM5C mediates ITIH1 expression and the PI3K/AKT signaling pathway to affect LIHC progression. (A) transfection efficacy of sh‐ITIH1 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) phosphorylation of PI3K/AKT in cells examined by western blot analysis; (C) proliferation of SNU‐387 and SK‐HEP‐1 cells determined by the CCK‐8 assay; (D), colony formation ability of SNU‐387 and SK‐HEP‐1 cells examined by the colony formation assay; (E) apoptosis rate in SNU‐387 and SK‐HEP‐1 cells examined by the TUNEL assay; (F–G) migration (F) and invasion (G) abilities of SNU‐387 and SK‐HEP‐1 cells determined by the wound‐healing and Transwell assays, respectively. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐KDM5C + sh‐NC group; # p < 0.01 versus the sh‐NC group
    Figure Legend Snippet: KDM5C mediates ITIH1 expression and the PI3K/AKT signaling pathway to affect LIHC progression. (A) transfection efficacy of sh‐ITIH1 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) phosphorylation of PI3K/AKT in cells examined by western blot analysis; (C) proliferation of SNU‐387 and SK‐HEP‐1 cells determined by the CCK‐8 assay; (D), colony formation ability of SNU‐387 and SK‐HEP‐1 cells examined by the colony formation assay; (E) apoptosis rate in SNU‐387 and SK‐HEP‐1 cells examined by the TUNEL assay; (F–G) migration (F) and invasion (G) abilities of SNU‐387 and SK‐HEP‐1 cells determined by the wound‐healing and Transwell assays, respectively. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐KDM5C + sh‐NC group; # p < 0.01 versus the sh‐NC group

    Techniques Used: Expressing, Transfection, Quantitative RT-PCR, Phospho-proteomics, Western Blot, CCK-8 Assay, Colony Assay, TUNEL Assay, Migration

    Downregulation of KDM5C inhibits growth of LIHC xenograft tumors in vivo. (A) Growth rate of the xenograft tumors in nude mice; (B) weight of the xenograft tumors on the 4th week; (C) protein levels of ITIH1 and Ki67 in tumor tissues examined by IHC. There were five mice in each group. Data were presented as mean ± SD from three independent experiments. Differences were analyzed by the unpaired t ‐test (B) or two‐way ANOVA (A and C), * p < 0.05 versus the sh‐NC group
    Figure Legend Snippet: Downregulation of KDM5C inhibits growth of LIHC xenograft tumors in vivo. (A) Growth rate of the xenograft tumors in nude mice; (B) weight of the xenograft tumors on the 4th week; (C) protein levels of ITIH1 and Ki67 in tumor tissues examined by IHC. There were five mice in each group. Data were presented as mean ± SD from three independent experiments. Differences were analyzed by the unpaired t ‐test (B) or two‐way ANOVA (A and C), * p < 0.05 versus the sh‐NC group

    Techniques Used: In Vivo



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    cell line sk-hep-1 cl-0212  (Procell Inc)
    90
    Procell Inc cell line sk-hep-1 cl-0212
    KDM5C is highly expressed in <t>LIHC</t> and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells
    Cell Line Sk Hep 1 Cl 0212, supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell line sk-hep-1 cl-0212/product/Procell Inc
    Average 90 stars, based on 1 article reviews
    cell line sk-hep-1 cl-0212 - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

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    KDM5C is highly expressed in LIHC and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: KDM5C is highly expressed in LIHC and indicates unfavorable patient prognosis. (A) Expression profiling of KDM5C in different cancer types predicted in the SangerBox system; (B) relevance of KDM5C expression to the overall survival rate of patients with LIHC; (C–D), mRNA (C) and protein (D) expression of KDM5C in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA, * p < 0.05 versus THLE‐3 cells

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Expressing, Quantitative RT-PCR, Western Blot

    Downregulation of KDM5C weakens proliferation, migration, and invasion, and increases apoptosis of LIHC cells. (A) interference efficiency of sh‐KDM5C 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) proliferation of cells examined by the CCK‐8 assay; (C) colony formation ability of cells determined by the colony formation assay; (D) apoptosis rate in cells examined by TUNEL assay; (E) migration ability of cells examined by the wound‐healing assay; (F) invasion ability of cells determined by the Transwell assay. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: Downregulation of KDM5C weakens proliferation, migration, and invasion, and increases apoptosis of LIHC cells. (A) interference efficiency of sh‐KDM5C 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) proliferation of cells examined by the CCK‐8 assay; (C) colony formation ability of cells determined by the colony formation assay; (D) apoptosis rate in cells examined by TUNEL assay; (E) migration ability of cells examined by the wound‐healing assay; (F) invasion ability of cells determined by the Transwell assay. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Migration, Quantitative RT-PCR, CCK-8 Assay, Colony Assay, TUNEL Assay, Wound Healing Assay, Transwell Assay

    ITIH1 level is negatively correlated with the KDM5C level in LIHC. (A) Genes showing a negative correlation with KDM5C in LIHC predicted in the Ualcan database (ranked in order of correlation; color depth of the blocks indicates the basic expression level of gene in LIHC); (B) expression profiling of ITIH1 in human cancers predicted in the SangerBox system; (C) correlation between ITIH1 and the survival of patients with LIHC predicted in the GEPIA database; (D) correlation between ITIH1 and KDM5C in patients with LIHC predicted in the Starbase system; (E and F) mRNA (E) and protein (F) levels of ITIH1 in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (E) and (F), differences were analyzed by one‐way ANOVA, * p < 0.05 versus the THLE‐3 cells

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: ITIH1 level is negatively correlated with the KDM5C level in LIHC. (A) Genes showing a negative correlation with KDM5C in LIHC predicted in the Ualcan database (ranked in order of correlation; color depth of the blocks indicates the basic expression level of gene in LIHC); (B) expression profiling of ITIH1 in human cancers predicted in the SangerBox system; (C) correlation between ITIH1 and the survival of patients with LIHC predicted in the GEPIA database; (D) correlation between ITIH1 and KDM5C in patients with LIHC predicted in the Starbase system; (E and F) mRNA (E) and protein (F) levels of ITIH1 in LIHC cell lines (Hep3B, SNU‐387, HuH‐7, and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by RT‐qPCR and western blot analysis, respectively. Data were presented as mean ± SD from three independent experiments. In panels (E) and (F), differences were analyzed by one‐way ANOVA, * p < 0.05 versus the THLE‐3 cells

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Expressing, Quantitative RT-PCR, Western Blot

    KDM5C removes H3K4me1 to reduce ITIH1 expression in LIHC cells. (A) Methylation modification at the promoter region of ITIH1 predicted in the UCSC database; (B) mRNA level of ITIH1 in cells transfected with sh‐KDM5C examined by RT‐qPCR; (C and D) H3K4me1 (C) and KDM5C (D) modification levels at ITIH1 promoter region in LIHC cell lines (Hep3B, SNU‐387, HuH‐7 and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by ChIP‐qPCR; E, protein levels of ITIH1 and H3K4me1 in cells transfected sh‐KDM5C examined by western blot analysis. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA; in panels (B)–(E), differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group; # p < 0.01 versus THLE‐3 cells

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: KDM5C removes H3K4me1 to reduce ITIH1 expression in LIHC cells. (A) Methylation modification at the promoter region of ITIH1 predicted in the UCSC database; (B) mRNA level of ITIH1 in cells transfected with sh‐KDM5C examined by RT‐qPCR; (C and D) H3K4me1 (C) and KDM5C (D) modification levels at ITIH1 promoter region in LIHC cell lines (Hep3B, SNU‐387, HuH‐7 and SK‐HEP‐1) and liver epithelial cells THLE‐3 examined by ChIP‐qPCR; E, protein levels of ITIH1 and H3K4me1 in cells transfected sh‐KDM5C examined by western blot analysis. Data were presented as mean ± SD from three independent experiments. In panels (C) and (D), differences were analyzed by one‐way ANOVA; in panels (B)–(E), differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐NC group; # p < 0.01 versus THLE‐3 cells

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Expressing, Methylation, Modification, Transfection, Quantitative RT-PCR, ChIP-qPCR, Western Blot

    KDM5C mediates ITIH1 expression and the PI3K/AKT signaling pathway to affect LIHC progression. (A) transfection efficacy of sh‐ITIH1 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) phosphorylation of PI3K/AKT in cells examined by western blot analysis; (C) proliferation of SNU‐387 and SK‐HEP‐1 cells determined by the CCK‐8 assay; (D), colony formation ability of SNU‐387 and SK‐HEP‐1 cells examined by the colony formation assay; (E) apoptosis rate in SNU‐387 and SK‐HEP‐1 cells examined by the TUNEL assay; (F–G) migration (F) and invasion (G) abilities of SNU‐387 and SK‐HEP‐1 cells determined by the wound‐healing and Transwell assays, respectively. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐KDM5C + sh‐NC group; # p < 0.01 versus the sh‐NC group

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: KDM5C mediates ITIH1 expression and the PI3K/AKT signaling pathway to affect LIHC progression. (A) transfection efficacy of sh‐ITIH1 1, 2, 3# in SNU‐387 and SK‐HEP‐1 cells examined by RT‐qPCR; (B) phosphorylation of PI3K/AKT in cells examined by western blot analysis; (C) proliferation of SNU‐387 and SK‐HEP‐1 cells determined by the CCK‐8 assay; (D), colony formation ability of SNU‐387 and SK‐HEP‐1 cells examined by the colony formation assay; (E) apoptosis rate in SNU‐387 and SK‐HEP‐1 cells examined by the TUNEL assay; (F–G) migration (F) and invasion (G) abilities of SNU‐387 and SK‐HEP‐1 cells determined by the wound‐healing and Transwell assays, respectively. Data were presented as mean ± SD from three independent experiments. In all panels, differences were analyzed by two‐way ANOVA, * p < 0.05 versus the sh‐KDM5C + sh‐NC group; # p < 0.01 versus the sh‐NC group

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: Expressing, Transfection, Quantitative RT-PCR, Phospho-proteomics, Western Blot, CCK-8 Assay, Colony Assay, TUNEL Assay, Migration

    Downregulation of KDM5C inhibits growth of LIHC xenograft tumors in vivo. (A) Growth rate of the xenograft tumors in nude mice; (B) weight of the xenograft tumors on the 4th week; (C) protein levels of ITIH1 and Ki67 in tumor tissues examined by IHC. There were five mice in each group. Data were presented as mean ± SD from three independent experiments. Differences were analyzed by the unpaired t ‐test (B) or two‐way ANOVA (A and C), * p < 0.05 versus the sh‐NC group

    Journal: The Kaohsiung Journal of Medical Sciences

    Article Title: Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma

    doi: 10.1002/kjm2.12501

    Figure Lengend Snippet: Downregulation of KDM5C inhibits growth of LIHC xenograft tumors in vivo. (A) Growth rate of the xenograft tumors in nude mice; (B) weight of the xenograft tumors on the 4th week; (C) protein levels of ITIH1 and Ki67 in tumor tissues examined by IHC. There were five mice in each group. Data were presented as mean ± SD from three independent experiments. Differences were analyzed by the unpaired t ‐test (B) or two‐way ANOVA (A and C), * p < 0.05 versus the sh‐NC group

    Article Snippet: Another two LIHC cell lines HuH‐7 (CL‐0120) and SK‐HEP‐1 (CL‐0212) were procured from Procell Life Science & Technology Co., Ltd. (Wuhan, Hubei, China).

    Techniques: In Vivo